Best Overall
Cortizone-10 Ultra Soothing Cream
Key details
- Form
- Cream
- Size
- 2 oz
- Moisturizers
- 10 moisturizers
- Active Ingredient
- Hydrocortisone 1%
The 2-ounce tube is the detail that makes this the one we keep in the medicine cabinet rather than a travel bag. It is big enough that we are not rationing it for a single mosquito bite, and the cream base rubs in without the heavy film that makes some ointments a chore. For most people, that combination of size and a non-greasy cream is the best default in this group, and it is the pick we reach for first.
The formula pairs 1% hydrocortisone with 10 moisturizers, which is why it feels more like a soothing lotion than a bare medicated cream. We appreciated that it spreads easily over a rash or a cluster of bites and does not leave a strong scent behind. It is still a medicated product, so we use it as directed and keep it away from broken skin.
What keeps it from being the answer for every itch is the format: a cream is easy for daytime and under clothes, but it will rub off faster than an ointment if you are sweating or getting wet. We still think the tube belongs in a first aid drawer, and the midrange price is easy to justify for the size. If you need a water-resistant barrier, step to an ointment; otherwise, the cream is the easier one to live with.
Pros
- 2-ounce tube suits a medicine cabinet
- Cream absorbs without a heavy film
- 10 moisturizers support dry, itchy skin
- 1% hydrocortisone at OTC maximum
Cons
- Cream can rub off with sweat or water
We make the Cortizone-10 Ultra Soothing Cream our top pick for most people: a 2-ounce tube of 1% hydrocortisone with 10 moisturizers and a non-greasy finish.